Detail publikace

Improved Disease Outcome Prediction Based on Microarray and Clinical Data Combination and Pre-validation

ŠILHAVÁ Jana a SMRŽ Pavel. Improved Disease Outcome Prediction Based on Microarray and Clinical Data Combination and Pre-validation. In: Biomedical Engineering Systems and Technologies. Valencia: Springer Verlag, 2010, s. 36-41. ISBN 978-3-540-92218-6.
Název česky
Improved disease outcome prediction based on microarray and clinical data combination and pre-validation
Typ
článek ve sborníku konference
Jazyk
angličtina
Autoři
Abstrakt

Combining relevant information from high-dimensional microarray data and low-dimensional clinical variables to predict disease outcome is important to improve treatment decisions. Such a combination may yield more accurate predictions than those obtained based on the use of microarray or clinical data alone. We propose a combination of logistic regression for clinical data and BinomialBoosting for microarray data. Then we propose its extension designed for redundant sets of data. Our approach combines microarray and clinical data at the level of decision integration. The extension includes pre-validation of models built with microarray and clinical data followed by weights calculation. Weights determine relevance of microarray and clinical models for data combination. Evaluations are performed with several redundant and non-redundant simulated datasets. Then some tests are applied to two real benchmark datasets. Our approach increases outcome prediction on non-redundant simulated datasets and does not decrease outcome prediction on redundant simulated datasets. Pre-validation of built models improves outcome of the prediction up to 4% in the case of real redundant dataset.

Rok
2010
Strany
36-41
Sborník
Biomedical Engineering Systems and Technologies
Konference
BIOINFORMATICS 2010, Hotel Sidi Saler, Valencia, Spain, ES
ISBN
978-3-540-92218-6
Vydavatel
Springer Verlag
Místo
Valencia, ES
BibTeX
@INPROCEEDINGS{FITPUB9125,
   author = "Jana \v{S}ilhav\'{a} and Pavel Smr\v{z}",
   title = "Improved Disease Outcome Prediction Based on Microarray and Clinical Data Combination and Pre-validation",
   pages = "36--41",
   booktitle = "Biomedical Engineering Systems and Technologies",
   year = 2010,
   location = "Valencia, ES",
   publisher = "Springer Verlag",
   ISBN = "978-3-540-92218-6",
   language = "english",
   url = "https://www.fit.vut.cz/research/publication/9125"
}
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