Conference paper

RUDOLFOVÁ Ivana. Combined Density- and Grid- Based Method for Clustering of Protein Substructures. In: ZNALOSTI 2009, Proceedings of the 8th annual conference. Brno: Vydavateµstvo STU, 2009, pp. 201-212. ISBN 978-80-227-3015-0.
Publication language:english
Original title:Combined Density- and Grid- Based Method for Clustering of Protein Substructures
Title (cs):Kombinovaná metoda pro shlukování proteinových substruktur
Pages:201-212
Proceedings:ZNALOSTI 2009, Proceedings of the 8th annual conference
Conference:Znalosti 2009
Place:Brno, CZ
Year:2009
ISBN:978-80-227-3015-0
Publisher:Vydavateµstvo STU
Keywords
Cluster analysis, data mining, PDB, sequence-structure fragments, protein structure prediction
Annotation
Data mining techniques may reveal interesting knowledge in various datasets. The biological databases are enormously large and therefore, data mining techniques could be extremely helpful to extract the knowledge from them. In our study, we focused on data mining in PDB - Protein Data Bank. We used cluster analysis to identify the sequences that occur in limited number of structural conformations (sequence-structure fragments). This knowledge about protein fragments can be used in protein structure predictions. In this paper, we present a combined density- and grid-based method that we developed for clustering of protein structures. We also compare this method with a simple density-based clustering method that we used in the first part of our study to prove the existence of protein sequences that occur in more than one structural conformation but the number of its structural conformations is limited.
BibTeX:
@INPROCEEDINGS{
   author = {Ivana Rudolfov{\'{a}}},
   title = {Combined Density- and Grid- Based Method for Clustering of
	Protein Substructures},
   pages = {201--212},
   booktitle = {ZNALOSTI 2009, Proceedings of the 8th annual conference},
   year = {2009},
   location = {Brno, CZ},
   publisher = {Vydavate{\'{l}}stvo STU},
   ISBN = {978-80-227-3015-0},
   language = {english},
   url = {http://www.fit.vutbr.cz/research/view_pub.php.en.iso-8859-2?id=8891}
}

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