Thesis Details

Bioinformatický nástroj pro predikci rozpustnosti proteinů

Bachelor's Thesis Student: Čermák Jiří Academic Year: 2016/2017 Supervisor: Martínek Tomáš, doc. Ing., Ph.D.
English title
Bioinformatics Tool for Prediction of Protein Solubility
Language
Czech
Abstract

To achieve cheaper and more efficient protein production, we must be able to predict protein solubility. In this thesis, we describe creation of bioinformatic data sets based on Target Track and eSol databases, we test the features used in existing protein solubility prediction tools and create a new predictor. Even though we fail to create an effective prediction tool we find out that in most cases the old features tested on the new data do not correlate with protein solubility as strongly as others repot in older and smaller datasets.

Keywords

Protein solubility, Machine learning, Protein Aggregation, Protein engineering, Protein synthesis

Department
Degree Programme
Information Technology
Files
Status
defended, grade D
Date
14 June 2017
Reviewer
Committee
Sekanina Lukáš, prof. Ing., Ph.D. (DCSY FIT BUT), předseda
Dytrych Jaroslav, Ing., Ph.D. (DCGM FIT BUT), člen
Hrubý Martin, Ing., Ph.D. (DITS FIT BUT), člen
Kořenek Jan, doc. Ing., Ph.D. (DCSY FIT BUT), člen
Švéda Miroslav, prof. Ing., CSc. (DIFS FIT BUT), člen
Citation
ČERMÁK, Jiří. Bioinformatický nástroj pro predikci rozpustnosti proteinů. Brno, 2017. Bachelor's Thesis. Brno University of Technology, Faculty of Information Technology. 2017-06-14. Supervised by Martínek Tomáš. Available from: https://www.fit.vut.cz/study/thesis/20048/
BibTeX
@bachelorsthesis{FITBT20048,
    author = "Ji\v{r}\'{i} \v{C}erm\'{a}k",
    type = "Bachelor's thesis",
    title = "Bioinformatick\'{y} n\'{a}stroj pro predikci rozpustnosti protein\r{u}",
    school = "Brno University of Technology, Faculty of Information Technology",
    year = 2017,
    location = "Brno, CZ",
    language = "czech",
    url = "https://www.fit.vut.cz/study/thesis/20048/"
}
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