Thesis Details

Prediktor vlivu aminokyselinových substitucí na stabilitu proteinů

Master's Thesis Student: Flax Michal Academic Year: 2016/2017 Supervisor: Musil Miloš, Ing., Ph.D.
English title
Predictor of the Effect of Amino Acid Substitutions on Protein Stability
Language
Czech
Abstract

This paper deals with prediction of influence of amino acids mutations on protein stability. The prediction is based on different methods of machine learning. Protein mutations are classified as mutations that increase or decrease protein stability. The application also predicts the magnitude of change in Gibbs free energy after the mutation.

Keywords

Stability of proteins, mutation, amino acids, machine learning, classification, regression, support vector machines, artificial neural networks, random forest.

Department
Department of Information Systems FIT BUT
Degree Programme
Information Technology, Field of Study Bioinformatics and Biocomputing
Files
Status
defended, grade B
Date
21 June 2017
Reviewer
Martínek Tomáš, doc. Ing., Ph.D.
Committee
Sekanina Lukáš, prof. Ing., Ph.D. (DCSY FIT BUT), předseda
Burgetová Ivana, Ing., Ph.D. (DIFS FIT BUT), člen
Horák Aleš, doc. RNDr., Ph.D. (FI MUNI), člen
Martínek Tomáš, doc. Ing., Ph.D. (DCSY FIT BUT), člen
Rogalewicz Adam, doc. Mgr., Ph.D. (DITS FIT BUT), člen
Zbořil František, doc. Ing., Ph.D. (DITS FIT BUT), člen
Citation
FLAX, Michal. Prediktor vlivu aminokyselinových substitucí na stabilitu proteinů. Brno, 2017. Master's Thesis. Brno University of Technology, Faculty of Information Technology. 2017-06-21. Supervised by Musil Miloš. Available from: https://www.fit.vut.cz/study/thesis/19295/
BibTeX 
@mastersthesis{FITMT19295,
    author = "Michal Flax",
    type = "Master's thesis",
    title = "Prediktor vlivu aminokyselinov\'{y}ch substituc\'{i} na stabilitu protein\r{u}",
    school = "Brno University of Technology, Faculty of Information Technology",
    year = 2017,
    location = "Brno, CZ",
    language = "czech",
    url = "https://www.fit.vut.cz/study/thesis/19295/"
}

Theses

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