Title:

Bioinformatics

Code:

IV108

Ac.Year:

2018/2019

Sem:

Winter

Curriculums:

Programme	Field	Year	Duty
CSE-PHD-4	DVI4	-	Elective

Language of Instruction:

Czech

Completion:

examination (verbal)

Type of
instruction:

Hour/sem	Lectures	Seminar Exercises	Laboratory Exercises	Computer Exercises	Other
Hours:	13	13	0	0	0
	Exams	Tests	Exercises	Laboratories	Other
Points:	100	0	0	0	0

Guarantor:

Lexa Matej, Ing., Ph.D. (FI)

Lecturer:

Lexa Matej, Ing., Ph.D. (FI)

Faculty:

Faculty of Informatics MU

Description:

An advanced course in bioinformatics (lecture and computer lab) building upon elementary mol.biology and/or bioinformatics courses.

Syllabus of lectures:

1. Biological language (sequence segmentation, information-statistical analysis of biological sequences)
2. Pattern matching (algoritms based on filtration and suffix arrays)
3. Heuristic algorithms for similarity searching in biological sequences (BLAST, BLAT, Pattern Hunter)
4. Regular expressions in bioinformatics
5. Algorithms for analysis and prediction of structural data (secondary strukture, contacts inb proteins, domain identification)
6. Algorithms for analysis and prediction of structural data (3D structure, structural comparisons)
7. Working with molecular structures in Pymol
8. New methods of DNA sequencing
9. Genome assembly and other operations on short nucleic acid sequences
10. Prediction of melting temperature in DNA and other nucleic acids (program mfold)
11. RNA secondary structure
12. DNA computing
13. Comparative genomics of human (analysis of scientific papers)

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Bioinformatics