Department of Information Systems

Conference paper

MUSIL Miloš, MARTÍNEK Tomáš and ZENDULKA Jaroslav. FireProt: web server for automated design of thermostable proteins. In: DAZ & WIKT 2018 Proceedings. Brno, 2018, pp. 1-4.
Publication language:english
Original title:FireProt: web server for automated design of thermostable proteins
Proceedings:DAZ & WIKT 2018 Proceedings
Conference:Data a znalosti 2018
Place:Brno, CZ
There is a continuous interest in increasing proteins stability to enhance their usability in numerous biomedical and biotechnological applications. Only a single-point mutations with a small impact on protein stability are typically predicted with the existing tools, while more complex multiple-point mutants are necessary for useful stabilization. Here, we present FireProt, a web server for automated design of multiplepoint thermostable mutants that combines structural and evolutionary information in its calculation core. The server is complemented with interactive, easy-to-use interface that allows users to directly analyze and optionally modify designed thermostable mutants.
   author = {Milo{\v{s}} Musil and Tom{\'{a}}{\v{s}}
	Mart{\'{i}}nek and Jaroslav Zendulka},
   title = {FireProt: web server for automated design of
	thermostable proteins},
   pages = {1--4},
   booktitle = {DAZ \& WIKT 2018 Proceedings},
   year = 2018,
   location = {Brno, CZ},
   language = {english},
   url = {}

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