Ing. Jiří Jaroš, Ph.D.

ROBERTSON James L., COX Ben T., JAROŠ Jiří and TREEBY Bradley E. Accurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulation. The Journal of the Acoustical Society of America. 2017, vol. 141, no. 3, pp. 1726-1738. ISSN 1520-8524. Available from:
Publication language:english
Original title:Accurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulation
Title (cs):Transkraniální simulací šíření ultrazvuku skrze lebku pro neuromodulaci a neurostimulaci
Journal:The Journal of the Acoustical Society of America, Vol. 141, No. 3, US
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Transcranial neurostimulation, focused ultrasound, numerical simulation
Non-invasive, focal neurostimulation with ultrasound is a potentially powerful neuroscientific tool that requires effective transcranial focusing of ultrasound to develop. Time-reversal (TR) focusing using numerical simulations of transcranial ultrasound propagation can correct for the effect of the skull, but relies on accurate simulations. Here, focusing requirements for ultrasonic neurostimula- tion are established through a review of previously employed ultrasonic parameters, and consider- ation of deep brain targets. The specific limitations of finite-difference time domain (FDTD) and k-space corrected pseudospectral time domain (PSTD) schemes are tested numerically to establish the spatial points per wavelength and temporal points per period needed to achieve the desired accuracy while minimizing the computational burden. These criteria are confirmed through conver- gence testing of a fully simulated TR protocol using a virtual skull. The k-space PSTD scheme performed as well as, or better than, the widely used FDTD scheme across all individual error tests and in the convergence of large scale models, recommending it for use in simulated TR. Staircasing was shown to be the most serious source of error. Convergence testing indicated that higher sampling is required to achieve fine control of the pressure amplitude at the target than is needed for accurate spatial targeting.
   author = {L. James Robertson and T. Ben Cox and Ji{\v{r}}{\'{i}}
	Jaro{\v{s}} and E. Bradley Treeby},
   title = {Accurate simulation of transcranial ultrasound propagation
	for ultrasonic neuromodulation and stimulation},
   pages = {1726--1738},
   journal = {The Journal of the Acoustical Society of America},
   volume = {141},
   number = {3},
   year = {2017},
   ISSN = {1520-8524},
   language = {english},
   url = {}

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