Ing. Jiří Jaroš, Ph.D.

SUOMI Visa, JAROŠ Jiří, TREEBY Bradley E. and CLEVELAND Robin. Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney. In: 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Orlando: Institute of Electrical and Electronics Engineers, 2016, pp. 5648-5651. ISBN 978-1-4577-0220-4. Available from: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7592008&isnumber=7590615
Publication language:english
Original title:Nonlinear 3-D simulation of high-intensity focused ultrasound therapy in the kidney
Title (cs):Nelineární 3-D simulace ultrazvukových terapií v ledvinách
Pages:5648-5651
Proceedings:38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Conference:The Engineering in Medicine and Biology Conference Management System
Place:Orlando, US
Year:2016
URL:http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7592008&isnumber=7590615
ISBN:978-1-4577-0220-4
Publisher:Institute of Electrical and Electronics Engineers
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Keywords
HIFU, k-Wave, ultrasound, kidney, 3D nonlinear simulation
Annotation
Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat, kidney and liver. The combined effect of inhomogeneous attenuation and soundspeed was found to result in an 11.0 dB drop in spatial peaktemporal average (SPTA) intensity in the kidney compared to pure water. The simulation without refraction effects showed a 6.3 dB decrease indicating that both attenuation and refraction contribute to the loss in focal intensity. The losses due to reflections at soft tissue interfaces were less than 0.1 dB. Focal point shifting due to refraction effects resulted in - 1.3, 2.6 and 1.3 mm displacements in x-, y- and z-directions respectively. Furthermore, focal point splitting into several smaller subvolumes was observed. The total volume of the secondary focal points was approximately 48% of the largest primary focal point. This could potentially lead to undesired heating outside the target location and longer therapy times.
BibTeX:
@INPROCEEDINGS{
   author = {Visa Suomi and Ji{\v{r}}{\'{i}} Jaro{\v{s}} and E. Bradley
	Treeby and Robin Cleveland},
   title = {Nonlinear 3-D simulation of high-intensity focused
	ultrasound therapy in the kidney},
   pages = {5648--5651},
   booktitle = {38th Annual International Conference of the IEEE Engineering
	in Medicine and Biology Society (EMBC)},
   year = {2016},
   location = {Orlando, US},
   publisher = {Institute of Electrical and Electronics Engineers},
   ISBN = {978-1-4577-0220-4},
   language = {english},
   url = {http://www.fit.vutbr.cz/research/view_pub.php?id=11177}
}

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