Product Details

PredictSNP: Robust and Accurate Consensus Classifier for Prediction of Disease-Related Mutations

Created: 2013

Czech title
PredictSNP: robustní a přesný klasifikátor pro predikci mutací asociovaných se vznikem onemocnění
Type
software
License
optional - free
Authors
Bendl Jaroslav, Ing. (DIFS FIT BUT)
Štourač Jan (LL)
Šalanda Ondřej, Ing. (FIT BUT)
Pavelka Antonín, RNDr. (LL)
Wieben Eric, Ph.D. (MAYO)
Zendulka Jaroslav, doc. Ing., CSc. (DIFS FIT BUT)
Brezovský Jan, Mgr., Ph.D. (LL)
Damborský Jiří, prof. Mgr., Dr. (LL)
Keywords

SNP, single nucleotide polymorphism, SNV, single nucleotide variant, pathogenicity prediction, disease-related mutations

Description

This tool estimates the effect of amino acid substitutions on protein function. The predictions are based on the results of the existing tools MAPP, PhD-SNP, PolyPhen-1, PolyPhen-2, SIFT and SNAP. The principle of consensual approach is described in: "Bendl et. al. (2014) PredictSNP: Robust and Accurate Consensus Classifier for Prediction of Disease-Related Mutations. PLoS Computational Biology, 10.". The user interface shows not only the overall results and the results of underlying tools but also the experimental annotations extracted from PMD and Uniprot databases.

Location
Licence

The tool is freely available for the academic community. It cannot be used for commercial purposes (to protect the rights of third parties - integrated methods with non-free licence).

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