Journal article

SUOMI Visa, TREEBY Bradley E., JAROŠ Jiří, MAKELA Pietari, ANTTINEN Mikael, SAUNAVAARA Jani, SAINIO Teija, KIVINIEMI Aida and BLANCO Roberto. Transurethral ultrasound therapy of the prostate in the presence of calcifications: a simulation study. Journal of Medical Physics. 111 River St., Hoboken, NJ 07030-5774: American Association of Physicists in Medicine, 2018, vol. 45, no. 11, pp. 4793-4804. ISSN 0094-2405. Available from: https://aapm.onlinelibrary.wiley.com/doi/abs/10.1002/mp.13183
Publication language:english
Original title:Transurethral ultrasound therapy of the prostate in the presence of calcifications: A simulation study
Title (cs):Transrektální ultrazvuková terapie prostaty za přítomnosti kalcifikací: simulační studie
Pages:4793-4804
Place:US
Year:2018
URL:https://aapm.onlinelibrary.wiley.com/doi/abs/10.1002/mp.13183
Journal:Journal of Medical Physics, Vol. 45, No. 11, 111 River St., Hoboken, NJ 07030-5774, US
ISSN:0094-2405
DOI:10.1002/mp.13183
Keywords
therapeutic ultrasound, prostate cancer, calcification, heating, efficacy
Annotation
Transurethral ultrasound therapy is an investigational treatment modality which could potentially be used for the localised treatment of prostate cancer. One of the limiting factors of this application are the prostatic calcifications which attenuate and reflect ultrasound, and thus, reduce the efficacy of the heating. The aim of this study is find out how prostatic calcifications affect the therapeutic efficacy and what is the best sonication strategy to overcome these limitations.

The presence of calcifications in front of the ultrasound field was found to increase the peak pressure by 100% on average while the maximum temperature only rose by 9% during a 20-second sonication. Losses in ultrasound energy were caused due to relative large acoustic impedance mismatch between the prostate tissue and the calcifications (1.63 vs. 3.20 MRayl) and high attenuation coefficient (0.78 vs. 2.64 dB/MHz^1.1/cm), which together left untreated tissue regions behind the calcifications. In addition, elevated temperatures were seen in the region between the transducer and the calcifications. Lower sonication frequencies (1-4 MHz) were not able to penetrate through the calcifications effectively, but longer sonication durations (20-60 s) with selected transducer elements were effective in treating the tissue regions behind the calcifications.

BibTeX:
@ARTICLE{
   author = {Visa Suomi and E. Bradley Treeby and
	Ji{\v{r}}{\'{i}} Jaro{\v{s}} and Pietari Makela
	and Mikael Anttinen and Jani Saunavaara and Teija
	Sainio and Aida Kiviniemi and Roberto Blanco},
   title = {Transurethral ultrasound therapy of the prostate
	in the presence of calcifications: A simulation
	study},
   pages = {4793--4804},
   journal = {Journal of Medical Physics},
   volume = {45},
   number = {11},
   year = {2018},
   ISSN = {0094-2405},
   doi = {10.1002/mp.13183},
   language = {english},
   url = {http://www.fit.vutbr.cz/research/view_pub.php.en?id=11733}
}

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